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Auteur Minguez, L.; Farcy, E.; Ballandonne, C.; Lepailleur, A.; Serpentini, A.; Lebel, J.M.; Bureau, R.; Halm-Lemeille, M.P.
Titre Acute toxicity of 8 antidepressants: What are their modes of action? Type Article scientifique
Année 2014 Publication Revue Abrégée Chemosphere
Volume 108 Numéro (up) Pages 314-319
Mots-Clés Daphnia magna; Haliotis tuberculata; Lysosomotropism; Multi-approach; Narcosis; Pharmaceutical; assessment; cationic amphiphilic drugs; cause foot detachment; cell-cultures; cytotoxicity; ecotoxicology; fluoxetine; hemocytes; human pharmaceuticals; pi interactions; water
Résumé Currently, the hazard posed by pharmaceutical residues is a major concern of ecotoxicology. Most of the antidepressants belong to a family named the Cationic Amphipathic Drugs known to have specific interactions with cell membranes. The present study assessed the impact of eight antidepressants belonging to selective serotonin reuptake inhibitors or serotonin norepinephrine reuptake inhibitors by the combination of multi-approaches (in vivo, in vitro, in silico) and gives some insights on the mode of action for these molecules. Antidepressants were from the most to the least toxic compound for Daphnia magna: Sertraline (EC50 = 1.15 mg L-1) > Clomipramine (2.74 mg L-1)> Amitriptyline (4.82 mg L-1)> Fluoxetine (5.91 mg L-1) > Paroxetine (6.24 mg L-1) > Mianserine (7.81 mg L-1) > Citalopram (30.14 mg L-1) and Venlafaxine (141.28 mg L-1). These acute toxicities were found correlated to Log K, coefficients (R = 0.93, p < 0.001) and to cytotoxicity assessed on abalone hemocytes through the neutral red uptake assay (R = 0.96, p < 0.001). If narcosis as mode of action is typically expected during acute ecotoxicity bioassays, we showed by molecular modeling that particular interactions can exist between antidepressants and phosphatidylcholine, a major component of cell membranes, leading to a more specific mode of action corresponding to a potential acidic hydrolysis of ester functions. (C) 2014 Elsevier Ltd. All rights reserved.
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Langue English Langue du Résumé Titre Original
Éditeur de collection Titre de collection Titre de collection Abrégé
Volume de collection Numéro de collection Edition
ISSN 0045-6535 ISBN Médium
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Numéro d'Appel MARBEC @ isabelle.vidal-ayouba @ collection 440
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Auteur Collos, Y.; Jauzein, C.; Ratmaya, W.; Souchu, P.; Abadie, E.; Vaquer, A.
Titre Comparing diatom and Alexandrium catenella/tamarense blooms in Thau lagoon: Importance of dissolved organic nitrogen in seasonally N-limited systems Type Article scientifique
Année 2014 Publication Revue Abrégée Harmful Algae
Volume 37 Numéro (up) Pages 84-91
Mots-Clés Ammonium; Growth rate; Non classical blooms; Organic nitrogen; alexandrium catenella/tamarense
Résumé Diatom blooms in Thau lagoon are always related to rain events leading to inputs of inorganic nutrients such as phosphate, ammonium and nitrate through the watershed with time lags of about 1 week. In contrast, blooms of Alexandrium catenella/tamarense can occur following periods of 3 weeks without precipitation and no significant input of conventional nutrients such as nitrate and phosphate. Field results also indicate a significant drop (from 22–25 to 15–16 μM over 3 days) in dissolved organic nitrogen (DON) at the bloom peak, as well as a significant inverse relationship between A. catenella/tamarense cell density and DON concentrations that is not apparent for diatom blooms. Such dinoflagellate blooms are also associated with elevated (6–9 μM) ammonium concentrations, a curious feature also observed by other investigators, possibly the results of ammonium excretion by this organism during urea or other organic nitrogen assimilation. The potential use of DON by this organism represents short cuts in the nitrogen cycle between plants and nutrients and requires a new model for phytoplankton growth that is different from the classical diatom bloom model. In contrast to such diatom blooms that are due to conventional (nitrate, phosphate) nutrient pulses, Alexandrium catenella/tamarense blooms on the monthly time scale are due to organic nutrient enrichment, a feature that allows net growth rates of about 1.3 d−1, a value higher than that generally attributed to such organisms.
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Langue Langue du Résumé Titre Original
Éditeur de collection Titre de collection Titre de collection Abrégé
Volume de collection Numéro de collection Edition
ISSN 1568-9883 ISBN Médium
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Numéro d'Appel MARBEC @ isabelle.vidal-ayouba @ collection 475
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Auteur Pommier, T.; Merroune, A.; Bettarel, Y.; Got, P.; Janeau, J.-L.; Jouquet, P.; Thu, T.D.; Toan, T.D.; Rochelle-Newall, E.
Titre Off-site impacts of agricultural composting: role of terrestrially derived organic matter in structuring aquatic microbial communities and their metabolic potential Type Article scientifique
Année 2014 Publication Revue Abrégée FEMS Microbiology Ecology
Volume Numéro (up) Pages n/a-n/a
Mots-Clés Metabolic potential; Off-site effects; Soil leachates; lakes
Résumé While considered as sustainable and low-cost agricultural amendments, the impacts of organic fertilizers on downstream aquatic microbial communities remain poorly documented. We investigated the quantity and quality of the dissolved organic matter leaching from agricultural soil amended with compost, vermicompost or biochar and assessed their effects on lake microbial communities, in terms of viral and bacterial abundances, community structure and metabolic potential. The addition of compost and vermicompost significantly increased the amount of dissolved organic carbon in the leachate compared to soil alone. Leachates from these additions, either with or without biochar were highly bioavailable to aquatic microbial communities, though reducing the metabolic potential of the community and harboring more specific communities. Although not affecting bacterial richness or taxonomic distributions, the specific addition of biochar affected the original lake bacterial communities resulting in a strongly different community. This could be partly explained by viral burst and converging bacterial abundances throughout the samples. These results underline the necessity to include off-site impacts of agricultural amendments when considering their cascading effect on downstream aquatic ecosystems. This article is protected by copyright. All rights reserved.
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Volume de collection Numéro de collection Edition
ISSN 1574-6941 ISBN Médium
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Numéro d'Appel MARBEC @ isabelle.vidal-ayouba @ collection 746
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Auteur Minguez, L.; Di Poi, C.; Farcy, E.; Ballandonne, C.; Benchouala, A.; Bojic, C.; Cossu-Leguille, C.; Costil, K.; Serpentini, A.; Lebel, J.-M.; Halm-Lemeille, M.-P.
Titre Comparison of the sensitivity of seven marine and freshwater bioassays as regards antidepressant toxicity assessment Type Article scientifique
Année 2014 Publication Revue Abrégée Ecotoxicology
Volume Numéro (up) Pages 1-11
Mots-Clés Antidepressant; Freshwater ecotoxicity; Marine ecotoxicity; Sensitivity comparison; Test battery
Résumé
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Langue English Langue du Résumé Titre Original
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Volume de collection Numéro de collection Edition
ISSN 0963-9292 ISBN Médium
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Numéro d'Appel MARBEC @ isabelle.vidal-ayouba @ collection 491
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Auteur Fouilland, E.; Vasseur, C.; Leboulanger, C.; Le Floc'h, E.; Carré, C.; Marty, B.; Steyer, J.-P.; Sialve, B.
Titre Coupling algal biomass production and anaerobic digestion: Production assessment of some native temperate and tropical microalgae Type Article scientifique
Année 2014 Publication Revue Abrégée Biomass & Bioenergy
Volume Numéro (up) Pages
Mots-Clés Digestates; Extreme natural environments; Wastewaters; chlorophyta; cyanobacteria; microalgae
Résumé Coupling algal biomass production and anaerobic digestion is one of the most promising bioprocesses for economically viable algal production. This study assesses the production rates of some native microalgae growing in media supplemented with algal digestate, urban wastewater or digested sludge. Native microalgal populations isolated from temperate freshwaters (Scenedesmus spp.) and marine ecosystems (Nannochloris spp.) had the highest potential production rates (about 100 mg DW L−1 d−1) with algal digestate at about 20% loading ratio. However, no growth was measured for Nannochloris spp., when the ammonium concentration exceeded 100 mg L−1 although Scenedesmus spp. appeared to be tolerant to higher NH4+ concentrations. Very low production rates, or no growth, were measured when microalgae isolated from high salinity waters (Dunaliella salina, Lyngbya aestuarii) were used, suggesting that populations well adapted to extreme environmental conditions are not suitable candidates for growing on wastewater or anaerobic digestate.
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Volume de collection Numéro de collection Edition
ISSN 0961-9534 ISBN Médium
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Numéro d'Appel MARBEC @ isabelle.vidal-ayouba @ collection 494
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