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Auteur (up) Geay, F.; Culi, E.S.I.; Corporeau, C.; Boudry, P.; Dreano, Y.; Corcos, L.; Bodin, N.; Vandeputte, M.; Zambonino-Infante, J.L.; Mazurais, D.; Cahu, C.L. url  doi
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  Titre Regulation of FADS2 expression and activity in European sea bass (Dicentrarchus labrax, L.) fed a vegetable diet Type Article scientifique
  Année 2010 Publication Revue Abrégée Comparative Biochemistry and Physiology B-Biochemistry and Molecular Biology  
  Volume 156 Numéro 4 Pages 237-243  
  Mots-Clés biosynthesis; FADS2 expression and activity; Hufa; Sea bass (Dicentrarchus labrax)  
  Résumé Supplies of marine fish oils are limited, and continued growth in aquaculture production dictates that lipid substitutes in fish diets must be used without compromising fish health and product quality. In this study, the total substitution of a fish meal and fish oil by a blend of vegetable meals (corn, soybean, wheat and lupin) and linseed oil in the diet of European sea bass (Dicentrachus labrax) was investigated. Two groups of European sea bass were fed with fish diet (FD) or vegetable diet (VD) for 9 months. VD, totally deprived of eicosapentaenoate (EPA; 20:5n-3) and docosahexaenoate (DHA; 22:6n-3), revealed a nutritional deficiency and affected growth performance. Whilst VD induced a significant increase in fatty acid desaturase 2 (FADS2) and sterol binding regulatory element-binding protein 1 (SREBP-1) mRNA levels, the desaturation rate of [1-C-14]18:3n-3 into [1-C-14]18:4n-3, analysed in microsomal preparations using HPLC method, did not show an upregulation of FADS2 activities in liver and intestine of fish fed VD. Moreover Western-blot analysis did not revealed any significant difference of FADS2 protein amount between the two dietary groups. These data demonstrate that sea bass exhibits a desaturase (FADS2) activity whatever their diet, but a post-transcriptional regulation of fads2 RNA prevents an increase of enzyme in fish fed a HUFA-free diet. This led to a lower fish growth and poor muscle HUFA content.  
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  ISSN 1096-4959 ISBN Médium  
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  Numéro d'Appel LL @ pixluser @ collection 75  
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