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Auteur (up) L'Honore, T.; Farcy, E.; Blondeau-Bidet, E.; Lorin-Nebel, C. doi  openurl
  Titre Inter-individual variability in freshwater tolerance is related to transcript level differences in gill and posterior kidney of European sea bass Type Article scientifique
  Année 2020 Publication Revue Abrégée Gene  
  Volume 741 Numéro Pages 144547  
  Mots-Clés chloride uptake; cl-cotransporter; dicentrarchus-labrax; fish ion regulation; Freshwater acclimation; gene-expression; Intraspecific variation; Ion transporters; marine teleost; nkcc; oreochromis-mossambicus; Osmoregulation; prlr; rainbow-trout; rich cells; slc26 anion transporters; slc26a6  
  Résumé Acclimation to low salinities is a vital physiological challenge for euryhaline fish as the European sea bass Dicentrarchus labrax. This species undertakes seasonal migrations towards lagoons and estuaries where a wide range of salinity variations occur along the year. We have previously reported intraspecific differences in freshwater tolerance, with an average 30% mortality rate. In this study, we bring new evidence of mechanisms underlying freshwater tolerance in sea bass at gill and kidney levels. In fresh water (FW), intraspecific differences in mRNA expression levels of several ion transporters and prolactin receptors were measured. We showed that the branchial Cl-/HCO3- anion transporter (slc26a6c) was over-expressed in freshwater intolerant fish, probably as a compensatory response to low blood chloride levels and potential metabolic alkalosis. Moreover, prolactin receptor a (prlra) and Na+/Cl- cotransporter (ncc1) but not ncc-2a expression seemed to be slightly increased and highly variable between individuals in freshwater intolerant fish. In the posterior kidney, freshwater intolerant fish exhibited differential expression levels of slc26 anion transporters and Na+/K+/2Cl(-) co-transporter 1b (nkcc1b). Lower expression levels of prolactin receptors (prlra, prlrb) were measured in posterior kidney which probably contributes to the failure in ion reuptake at the kidney level. Freshwater intolerance seems to be a consequence of renal failure of ion reabsorption, which is not sufficiently compensated at the branchial level.  
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  Langue English Langue du Résumé Titre Original  
  Éditeur de collection Titre de collection Titre de collection Abrégé  
  Volume de collection Numéro de collection Edition  
  ISSN 0378-1119 ISBN Médium  
  Région Expédition Conférence  
  Notes WOS:000526116400015 Approuvé pas de  
  Numéro d'Appel MARBEC @ isabelle.vidal-ayouba @ collection 2768  
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