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Auteur (up) van der Oost, R.; McKenzie, D.J.; Verweij, F.; Satumalay, C.; van der Molen, N.; Winter, M.J.; Chipman, J.K. doi  openurl
  Titre Identifying adverse outcome pathways (AOP) for Amsterdam city fish by integrated field monitoring Type Article scientifique
  Année 2020 Publication Revue Abrégée Environ. Toxicol. Pharmacol.  
  Volume 74 Numéro Pages 103301  
  Mots-Clés Adverse outcome pathways; bioanalytical strategy; Biochemical & physiological biomarkers; biomarker responses; Ecological studies; eel anguilla-anguilla; environmental risk-assessment; Micropollutants risk assessment; oxygen-consumption; rainbow-trout; sole parophrys-vetulus; swimming performance; trout oncorhynchus-mykiss; xenobiotic-metabolizing enzymes  
  Résumé The European City Fish project aimed to develop a generic methodology for ecological risk assessment for urban rivers. Since traditional methods only consider a small fraction of substances present in the water cycle, biological effect monitoring is required for a more reliable assessment of the pollution status. A major challenge for environmental risk assessment (ERA) is the application of adverse outcome pathways (AOP), i.e. the linking of pollutant exposure via early molecular and biochemical changes to physiological effects and, ultimately, effects on populations and ecosystems. We investigated the linkage between responses at these different levels. Many AOP aspects were investigated, from external and internal exposure to different classes of micropollutants, via molecular key events (MICE) the impacts on organs and organisms (fish physiology), to changes in the population dynamics of fish. Risk assessment procedures were evaluated by comparing environmental quality standards, bioassay responses, biomarkers in caged and feral fish, and the impact on fish populations. Although no complete AOP was observed, indirect relationships linking pollutant exposure via MICE to impaired locomotion were demonstrated at the most polluted site near a landfill for chemical waste. The pathway indicated that several upstream key events requiring energy for stress responses and toxic defence are likely to converge at a single common MKE: increased metabolic demands. Both fish biomarkers and the bioanalytical SIMONI strategy are valuable indicators for micropollutant risks to fish communities.  
  Auteur institutionnel Thèse  
  Editeur Lieu de Publication Éditeur  
  Langue English Langue du Résumé Titre Original  
  Éditeur de collection Titre de collection Titre de collection Abrégé  
  Volume de collection Numéro de collection Edition  
  ISSN 1382-6689 ISBN Médium  
  Région Expédition Conférence  
  Notes WOS:000514007200016 Approuvé pas de  
  Numéro d'Appel MARBEC @ isabelle.vidal-ayouba @ collection 2753  
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