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Auteur (up) Delcourt, N.; Lagrange, E.; Abadie, E.; Fessard, V.; Fremy, J.-M.; Vernoux, J.-P.; Peyrat, M.-B.; Maignien, T.; Arnich, N.; Molgo, J.; Mattei, C. doi  openurl
  Titre Pinnatoxins' Deleterious Effects on Cholinergic Networks: From Experimental Models to Human Health Type Article scientifique
  Année 2019 Publication Revue Abrégée Mar. Drugs  
  Volume 17 Numéro 7 Pages 425  
  Mots-Clés acute neurotoxicity; block; cyclic imines; dinoflagellate; human intoxication; myasthenia gravis; myasthenia-gravis; neuromuscular-transmission; nicotinic acetylcholine receptors; nicotinic acetylcholine-receptors; pinnatoxins; rat diaphragm; toxicity; toxins; Vulcanodinium rugosum; vulcanodinium-rugosum  
  Résumé Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been reported to date although acute toxicity was induced by PnTxs in rodents. LD50 values have been estimated for the different PnTXs through the oral route. At sublethal doses, all symptoms are reversible, and no neurological sequelae are visible. These symptoms are consistent with impairment of central and peripheral cholinergic network functions. In fact, PnTXs are high-affinity competitive antagonists of nicotinic acetylcholine receptors (nAChRs). Moreover, their lethal effects are consistent with the inhibition of muscle nAChRs, inducing respiratory distress and paralysis. Human intoxication by ingestion of PnTXs could result in various symptoms observed in episodes of poisoning with natural nAChR antagonists. This review updates the available data on PnTX toxicity with a focus on their mode of action on cholinergic networks and suggests the effects that could be extrapolated on human physiology.  
  Auteur institutionnel Thèse  
  Editeur Lieu de Publication Éditeur  
  Langue English Langue du Résumé Titre Original  
  Éditeur de collection Titre de collection Titre de collection Abrégé  
  Volume de collection Numéro de collection Edition  
  ISSN 1660-3397 ISBN Médium  
  Région Expédition Conférence  
  Notes WOS:000478650600036 Approuvé pas de  
  Numéro d'Appel MARBEC @ isabelle.vidal-ayouba @ collection 2622  
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