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Auteur (up) Legradi, J.B.; Di Paolo, C.; Kraak, M.H.S.; van der Geest, H.G.; Schymanski, E.L.; Williams, A.J.; Dingemans, M.M.L.; Massei, R.; Brack, W.; Cousin, X.; Begout, M.-L.; van der Oost, R.; Carion, A.; Suarez-Ulloa, V.; Silvestre, F.; Escher, B.I.; Engwall, M.; Nilen, G.; Keiter, S.H.; Pollet, D.; Waldmann, P.; Kienle, C.; Werner, I.; Haigis, A.-C.; Knapen, D.; Vergauwen, L.; Spehr, M.; Schulz, W.; Busch, W.; Leuthold, D.; Scholz, S.; vom Berg, C.M.; Basu, N.; Murphy, C.A.; Lampert, A.; Kuckelkorn, J.; Grummt, T.; Hollert, H. doi  openurl
  Titre An ecotoxicological view on neurotoxicity assessment Type Article scientifique
  Année 2018 Publication Revue Abrégée Environ. Sci Eur.  
  Volume 30 Numéro Pages 46  
  Mots-Clés Behaviour; zebrafish danio-rerio; environmental risk-assessment; acetylcholinesterase inhibitors; adverse outcome pathways; aop; Computational toxicity; developmental neurotoxicity; diesel exhaust; Eco-neurotoxicity; Ecological; eda; effect-directed analysis; lateral-line; Neurotoxicity; performance liquid-chromatography; reach; Species; swimming behavior  
  Résumé The numbers of potential neurotoxicants in the environment are raising and pose a great risk for humans and the environment. Currently neurotoxicity assessment is mostly performed to predict and prevent harm to human populations. Despite all the efforts invested in the last years in developing novel in vitro or in silico test systems, in vivo tests with rodents are still the only accepted test for neurotoxicity risk assessment in Europe. Despite an increasing number of reports of species showing altered behaviour, neurotoxicity assessment for species in the environment is not required and therefore mostly not performed. Considering the increasing numbers of environmental contaminants with potential neurotoxic potential, eco-neurotoxicity should be also considered in risk assessment. In order to do so novel test systems are needed that can cope with species differences within ecosystems. In the field, online-biomonitoring systems using behavioural information could be used to detect neurotoxic effects and effect-directed analyses could be applied to identify the neurotoxicants causing the effect. Additionally, toxic pressure calculations in combination with mixture modelling could use environmental chemical monitoring data to predict adverse effects and prioritize pollutants for laboratory testing. Cheminformatics based on computational toxicological data from in vitro and in vivo studies could help to identify potential neurotoxicants. An array of in vitro assays covering different modes of action could be applied to screen compounds for neurotoxicity. The selection of in vitro assays could be guided by AOPs relevant for eco-neurotoxicity. In order to be able to perform risk assessment for eco-neurotoxicity, methods need to focus on the most sensitive species in an ecosystem. A test battery using species from different trophic levels might be the best approach. To implement eco-neurotoxicity assessment into European risk assessment, cheminformatics and in vitro screening tests could be used as first approach to identify eco-neurotoxic pollutants. In a second step, a small species test battery could be applied to assess the risks of ecosystems.  
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  Langue English Langue du Résumé Titre Original  
  Éditeur de collection Titre de collection Titre de collection Abrégé  
  Volume de collection Numéro de collection Edition  
  ISSN 2190-4715 ISBN Médium  
  Région Expédition Conférence  
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  Numéro d'Appel MARBEC @ alain.herve @ collection 2485  
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