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Auteur Sadoul, B.; Alfonso, S.; Bessa, E.; Bouchareb, A.; Blondeau-Bidet, E.; Clair, P.; Chatain, B.; Begout, M.L.; Geffroy, B. doi  openurl
  Titre Enhanced brain expression of genes related to cell proliferation and neural differentiation is associated with cortisol receptor expression in fishes Type Article scientifique
  Année 2018 Publication Revue Abrégée Gen. Comp. Endocrinol.  
  Volume 267 Numéro Pages 76-81  
  Mots-Clés behavior; dehydrogenase; european sea bass; Glucocorticoid receptor; glucocorticoid-receptor; Hypothalamo-pituitary-interrenal axis; Mineralocorticoid receptor; neurogenesis; Neurogenesis; plasticity; rainbow-trout; real-time pcr; stress; Stress; zebrafish  
  Résumé Stress enhances or inhibits neurogenesis in mammals and some fish species. The link between the two processes is still unclear. Most studies have been performed in very specific stressful or altered environments. Despite the known inter-individual divergence in coping abilities within populations, the relationship between the stress axis and neurogenesis has never been addressed in unstressed individuals. Here we correlate brain expression of the pcna (proliferating cell nuclear antigen) and neurod1 (neurogenic differentiation factor 1) genes, two markers of neurogenesis, with transcripts of cortisol receptors in three fish species living in very distinct environments. Within the three species, individuals with the highest expression of neurogenesis genes were also those that expressed the high levels of cortisol receptors. Based on these correlations and the hypothesis that mRNA levels are proxies of protein levels, we hypothesize that within unstressed animals, individuals sensitive to cortisol perceive a similar environment to be more stimulating, leading to increased neurogenesis. Although it is difficult to determine whether it is sensitivity to cortisol that affects neurogenesis capacities or the opposite, the proposed pathway is a potentially fruitful avenue that warrants further mechanistic experiments.  
  Auteur institutionnel Thèse  
  Editeur Lieu de Publication Éditeur  
  Langue English Langue du Résumé Titre Original  
  Éditeur de collection Titre de collection Titre de collection Abrégé  
  Volume de collection Numéro de collection Edition (up)  
  ISSN 0016-6480 ISBN Médium  
  Région Expédition Conférence  
  Notes Approuvé pas de  
  Numéro d'Appel MARBEC @ alain.herve @ collection 2416  
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