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Auteur (up) Paiola, M.; Knigge, T.; Duflot, A.; Pinto, P.I.S.; Farcy, E.; Monsinjon, T. doi  openurl
  Titre Oestrogen, an evolutionary conserved regulator of T cell differentiation and immune tolerance in jawed vertebrates? Type Article scientifique
  Année 2018 Publication Revue Abrégée Dev. Comp. Immunol.  
  Volume 84 Numéro Pages 48-61  
  Mots-Clés bass dicentrarchus-labrax; danio-rerio; dendritic cells; estradiol; european sea-bass; Gamma-delta T cell; gene-expression; Head-kidney; receptor modulators; Regulatory T cell; reproductive-cycle; Spleen; Teleost; thymic epithelial-cells; Thymus; zebrafish  
  Résumé In teleosts, as in mammals, the immune system is tightly regulated by sexual steroid hormones, such as oestrogens. We investigated the effects of 17 beta-oestradiol on the expression of several genes related to T cell development and resulting T cell subpopulations in sea bass, Dicentrarchus labrax, for a primary lymphoid organ, the thymus, and two secondary lymphoid organs, the head-kidney and the spleen. In parallel, the oxidative burst capacity was assessed in leucocytes of the secondary lymphoid organs. Apoptosis- and proliferation-related genes, indicative of B and T cell clonal selection and lymphoid progenitor activity, were not affected by elevated oestrogen-levels. Sex-related oestrogen-responsiveness in T cell and antigen-presenting cell markers was observed, the expression of which was differentially induced by oestrogen-exposure in the three lymphoid organs. Remarkably, in the spleen, oestrogen increased regulatory T cell-related gene expression was associated with a decrease in oxidative burst capacity. To the best of our knowledge, this study indicates for the first time that physiological levels of oestrogen are likely to promote immune tolerance by modulating thymic function (i.e., T cell development and output) and peripheral T cells in teleosts, similar to previously reported oestrogenic effects in mammals. (C) 2018 Elsevier Ltd. All rights reserved.  
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  Langue English Langue du Résumé Titre Original  
  Éditeur de collection Titre de collection Titre de collection Abrégé  
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  ISSN 0145-305x ISBN Médium  
  Région Expédition Conférence  
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  Numéro d'Appel MARBEC @ alain.herve @ collection 2340  
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